Decreased Contents of Surfactant Proteins
نویسندگان
چکیده
Hydrophilic surfactant proteins, surfactant protein A (SP-A) and surfactant protein D (SP-D), have impor¬ tant roles in modulating the host defense functions in the peripheral airways. It has been reported that cig¬ arette smoke may alter the component and function of pulmonary surfactant. In this study, we determined the contents of SP-A and SP-D in BAL fluids ofhealthy smokers and nonsmokers by enzyme-linked immun¬ osorbent assay using monoclonal antibodies against each protein. The contents of SP-A and SP-D in BAL fluids were significandy (p<0.05) decreased in smokers compared to those in nonsmokers, although there was
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تاریخ انتشار 2007